Generic Name: eculizumab (E kue LIZ oo mab)
Brand Names: Soliris
What is eculizumab?
Eculizumab is a monoclonal antibody that binds to proteins in the blood that can destroy red blood cells in people with a genetic condition that affects the natural defenses of red blood cells.
Eculizumab is used to prevent the breakdown of red blood cells in people with paroxysmal nocturnal hemoglobinemia (PNH).
Eculizumab is also used to treat a rare chronic blood disease called atypical hemolytic (HEEM-oh-LIT-ik yoo-REEM-ik) uremic syndrome.
Eculizumab may also be used for purposes not listed in this medication guide.
What is the most important information I should know about eculizumab?
Do not shake the eculizumab vial (bottle) or you may ruin the medicine. Eculizumab affects your immune system, and using this medication may increase your risk of serious infection such as meningitis. You must be vaccinated against meningococcal infection at least 2 weeks before you start treatment with eculizumab. If you have been vaccinated in the past, you may need a booster dose. Call your doctor at once if you have a serious side effect such as severe headache, high fever, chills, stiffness in your neck or back, confusion, sensitivity to bright light, purple spots on the skin, nausea or vomiting, and/or seizure (convulsions). With your medication you will receive a Patient Safety Card listing the symptoms of meningococcal infection. Carry this card with you at all times. Seek emergency medical attention or call your doctor right away if you notice any of these symptoms. You should not use this medication if you are allergic to eculizumab, if you have bacterial meningitis, or if you have not been vaccinated against meningitis.
Before using eculizumab, tell your doctor if you have a fever or any type of infection.
Do not stop using eculizumab without first talking to your doctor. Stopping or interrupting your treatment could cause sudden and serious effects on your red blood cells. This may result in symptoms such as pale skin, easy bruising, confusion, chest pain, blood clots, or kidney problems.
Eculizumab is available only under a special program called Soliris REMS. You must be registered in the program and sign documents stating that you understand the risks and benefits of taking this medication.
What should I discuss with my health care provider before taking eculizumab?
Eculizumab affects your immune system, and using this medication may increase your risk of serious infection such as meningitis. Get emergency medical help if you have any signs of meningitis, such as severe headache with fever, confusion, purple spots on the skin, and nausea or vomiting, stiffness in your neck or back, sensitivity to bright light, or a high fever (103 degrees or higher), chills, body aches, and other flu-like symptoms. You must be vaccinated against meningococcal infection at least 2 weeks before you start treatment with eculizumab. If you have been vaccinated in the past, you may need a booster dose. It is best to stay current on all of your vaccinations while you are using eculizumab, and your doctor may recommend other vaccines before or during treatment. You should not use this medication if you are allergic to eculizumab, if you have bacterial meningitis, or if you have not been vaccinated against meningitis.
With your medication you will receive a Patient Safety Card listing the symptoms of meningococcal infection. Carry this card with you at all times. Seek emergency medical attention or call your doctor right away if you notice any of these symptoms.
Eculizumab is available only under a special program called Soliris REMS. You must be registered in the program and sign documents stating that you understand the risks and benefits of taking this medication.
To make sure you can safely use eculizumab, tell your doctor if you have a fever or any type of infection.
FDA pregnancy category C. It is not known whether eculizumab will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether eculizumab passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
How is eculizumab given?
Eculizumab is injected into a vein through an IV. You may be shown how to use an IV at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.
Eculizumab is usually given every 7 days for 5 weeks, and then once every 2 weeks thereafter. Follow your doctor's instructions. The medicine must be given slowly through an IV infusion, and can take up to 2 hours to complete.
You may have a reaction to the infusion (when the medicine is injected into the vein). If this happens, you may need to slow down the speed of your IV infusion, and the infusion should not take more than 2 hours to complete. A caregiver or family member should then watch you for at least 1 hour after your injection to make sure you have no further side effects.
Eculizumab must be mixed in an IV bag with a liquid (diluent) before injecting it. If you are using the injections at home, be sure you understand how to properly mix and store the medication.
Do not shake the medication vial (bottle) or you may ruin the medicine. Prepare your dose in a syringe only when you are ready to give yourself an injection. Do not use the medication if it has changed colors or has particles in it. Call your doctor for a new prescription. To reduce discomfort from your injection, allow the mixed medicine to reach room temperature before using, but never warm the medicine in hot water or a microwave. You may store the mixture at room temperature but you must use it within 24 hours or throw the mixture away.
Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.
Do not stop using eculizumab without first talking to your doctor. Stopping or interrupting your treatment could cause sudden and serious effects on your red blood cells. This may result in symptoms such as pale skin, easy bruising, confusion, chest pain, blood clots, or kidney problems.
If you stop using eculizumab for any reason, your blood may need to be tested on a regular basis for 8 to 12 weeks. Do not miss any scheduled visits to your doctor during this follow-up period.
Store in the refrigerator. Protect from light and do not freeze. Keep unopened eculizumab vials in their original carton. Throw away any unused vials after the expiration date on the label has passed.
What happens if I miss a dose?
Call your doctor for instructions if you miss a dose of this medication.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking eculizumab?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Eculizumab side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:
severe headache with fever, confusion, purple spots on the skin, nausea or vomiting, and/or seizure (convulsions);
stiffness in your neck or back;
sensitivity to bright light;
high fever (103 degrees or higher), chills, body aches, flu symptoms;
pain or burning when you urinate;
any signs of a new illness or infection; or
signs that the medication is not working (pale skin, easy bruising, weakness, dark urine, feeling short of breath, or sudden numbness, severe headache, deep leg pain, or problems with vision, speech, or balance).
Less serious side effects may include:
nausea;
diarrhea;
mild headache;
runny nose, sore throat; or
back pain.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Eculizumab Dosing Information
Usual Adult Dose for Paroxysmal Nocturnal Hemoglobinuria:
Initial dose: 600 mg via 35 minute IV infusion every 7 days for the first 4 weeks, followed by 900 mg for the fifth dose 7 days later.
Maintenance dose: 900 mg via 35 minute IV infusion every 14 days.
Usual Adult Dose for Hemolytic Uremic Syndrome:
Atypical Hemolytic Uremic Syndrome:
Initial dose: 900 mg via 35 minute IV infusion every 7 days for the first 4 weeks, followed by 1200 mg for the fifth dose 7 days later.
Maintenance dose: 1200 mg via 35 minute IV infusion every 14 days.
Usual Pediatric Dose for Hemolytic Uremic Syndrome:
Patient body weight 40 kg or more: Initial dose: 900 mg via 35 minute IV infusion every 7 days for the first 4 weeks, followed by 1200 mg for the fifth dose 7 days later.
Maintenance dose: 1200 mg via 35 minute IV infusion every 14 days.
Patient body weight 30 kg to less than 40 kg: Initial dose: 600 mg via 35 minute IV infusion every 7 days for the first 2 weeks, followed by 900 mg for the third dose 7 days later.
Maintenance dose: 900 mg via 35 minute IV infusion every 14 days.
Patient body weight 20 kg to less than 30 kg: Initial dose: 600 mg via 35 minute IV infusion every 7 days for the first 2 weeks, followed by 600 mg for the third dose 7 days later.
Maintenance dose: 600 mg via 35 minute IV infusion every 14 days.
Patient body weight 10 kg to less than 20 kg: Initial dose: 600 mg via 35 minute IV infusion once, followed by 300 mg for the second dose 7 days later.
Maintenance dose: 300 mg via 35 minute IV infusion every 14 days.
Patient body weight 5 kg to less than 10 kg: Initial dose: 300 mg via 35 minute IV infusion once, followed by 300 mg for the second dose 7 days later.
Maintenance dose: 300 mg via 35 minute IV infusion every 21 days.
What other drugs will affect eculizumab?
There may be other drugs that can interact with eculizumab. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
More eculizumab resources
- Eculizumab Side Effects (in more detail)
- Eculizumab Dosage
- Eculizumab Use in Pregnancy & Breastfeeding
- Eculizumab Drug Interactions
- Eculizumab Support Group
- 0 Reviews for Eculizumab - Add your own review/rating
- eculizumab Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information
- Eculizumab Professional Patient Advice (Wolters Kluwer)
- Eculizumab MedFacts Consumer Leaflet (Wolters Kluwer)
- Eculizumab Monograph (AHFS DI)
- Soliris Prescribing Information (FDA)
- Soliris Consumer Overview
Compare eculizumab with other medications
- Hemolytic Uremic Syndrome
- Myasthenia Gravis
- Paroxysmal Nocturnal Hemoglobinuria
Where can I get more information?
- Your pharmacist can provide more information about eculizumab.
See also: eculizumab side effects (in more detail)
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